FRONTIERS IN ENDOSCOPY, SERIES #27Endoscopic Approaches to Diagnose Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis
Patients with PSC have a lifetime risk of developing CCA of 10-15%. The ability to distinguish between benign strictures and CCA can be challenging as they may have similar appearances on imaging ERCP and MRCP. Here, we will review the different endoscopic techniquies to diagnose CCA in patients with PSC, as well as their success rates, risks and benefits.
COLORECTAL CANCER: REAL PROGRESS IN DIAGNOSIS AND TREATMENT, SERIES #5Stool DNA Testing: Are We There Today?
Screening for colorectal cancer is one of the most effective public health interventions. First- generation stool DNA tests demonstrated better sensitivity for colorectal cancer than fecal occult blood tests. Improvements to stool DNA tests have made them more sensitive and less complex. The newer marker panels can detect the vast majority of colorectal cancers and a large proportion of advanced adenomas, regardless of location in the colon. This review summarizes the development and advances to stool DNA testing for colorectal cancer.
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #153Vitamin D Deficiencies in Patients with Disorders of the Digestive System: Current Knowledge and Practical Considerations
There is a considerably high prevalence of vitamin D deficiency in patients with various disorders of the digestive system, including cystic fibrosis, acute and chronic pancreatitis, celiac disease, short bowel syndrome and inflammatory bowel disease. In this article, we discuss the different causes of the vitamin D deficiency and the different strategies for normalization of the vitamin D status in patients.
A CASE REPORTAll-Purpose Palliative Endoscopy in Pancreatic Cancer
Differences in IBD Care Between Adult and Pediatric Gastroenterologists
There has been a significant discussion about the transition of pediatric patients with inflammatory bowel disease (IBD) to adult gastroenterology care. The authors of this study attempted to evaluate for IBD clinical practice differences between adult and pediatric gastroenterologists and to compare these patterns of care with established clinical guidelines.
Probiotics and Protection Against Type I Diabetes Mellitus
Alterations in the infant intestinal microbiome potentially can lead to an increased risk of autoimmune disease, such as Type 1 Diabetes Mellitus (T1DM), and animal models have already suggested a link between increased gut biodiversity and a reduced risk of autoimmune diabetes. The authors of this study used data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, an international prospective cohort study attempting to identify causes of T1DM.
Are There Biochemical Markers for Necrotizing Enterocolitis?
Necrotizing enterocolitis (NEC) is an intestinal inflammatory disease leading to bowel necrosis, and it is a significant cause of death in premature infants. Its cause is unknown although intestinal permeability and bacterial translocation likely are contributing causes. The authors of this study considered if the proteome (the entire protein amount expressed by the genome) and the metabolome (the entire set of small molecules found in a biologic sample) of patients could predict severity of NEC.
TAKEDA PRESENTS ANALYSES FROM VEDOLIZUMAB DATA IN ULCERATIVE COLITIS AT 2016 DIGESTIVE DISEASE WEEK (DDW) ANNUAL MEETING
OSAKA, JAPAN - Takeda Pharmaceutical Company Limited [TSE: 4502], (Takeda) announced the oral presentations of two data analyses: one evaluating the optimal position of vedolizumab in the ulcerative colitis (UC) treatment paradigm, and a second separate analysis assessing whether early vedolizumab trough levels were associated with subsequent drug efficacy.